The Limit of Detection (LoD) and Limit of Quantification (LoQ) are analytical benchmarks that define the practical boundaries for identifying and measuring a specific analyte within a given matrix, under particular experimental conditions.

In this ever-evolving world where technology and science keep pushing into new territory, new inventions are being made and state-of-the-art validation methods are being developed. Over the last few decades, lithium-ion batteries have gained more and more traction in their uses, moving from general simple batteries used for powering your calculator or phone, to cars and trucks, and even airplanes (currently only the small ones). However, as simple as batteries may seem, a lot of work must be done behind to scenes to develop these subtle but priceless additions to our lives.

In the agrochemical industry, quantifying active ingredients containing fluorine can be simplified by using 19F benchtop NMR instead of other nuclides proton. Read more to find out how.

Fluorine-19 is one of the most popular nuclides in NMR, along with 1H, 13C and 31P. It has a relatively large chemical shift window (-300 to 400 ppm), which minimizes signal overlap even at low fields, is 100% naturally abundant, and its sensitivity is nearly as high as proton. Read more.

BODIPY dyes, which are boron difluoride compounds supported by dipyrrinato ligands, have gained recognition as being one of the more versatile fluorophores due to their superior photophysical properties.[1,2] BODIPY derivatives are used as stable functional dyes in several fields such as light harvesters, laser dyes, fluorescent switches, and biomolecular labels.[3-6] They gained popularity as biological probes due to the easy modification of the ligand framework, extension of the chromophore, and substitution of the fluorine atoms.6 Figure 1 shows some commercially available BODIPY dyes used as biological probes.

In this ever-evolving world where technology and science keep pushing into new territory, new inventions are being made and state-of-the-art validation methods are being developed. Over the last few decades, lithium-ion batteries have gained more and more traction in their uses, moving from general simple batteries used for powering your calculator or phone, to cars and trucks, and even airplanes (currently only the small ones). However, as simple as batteries may seem, a lot of work must be done behind to scenes to develop these subtle but priceless additions to our lives.

In this blog post, we show an example for on-line flow reaction monitoring via 19F NMR spectroscopy using the compact benchtop NMR. 1-855-NMREADY (667-3239) toll-free in the US and Canada

2D NMR experiments provide chemists with evidence to clarify and confirm resonance assignment.  Nowadays every organic chemist uses these experiments called COSY, HMBC and HSQC as routine analytics. Basically, with 2D experiments you correlate some kind of information between two 1D spectra. If we correlate two 1D spectra of the same nucleus we are dealing with homonuclear 2D NMR experiments. The most famous representative of this group is the COSY experiment (find theory here and application here).

BODIPY dyes, which are boron difluoride compounds supported by dipyrrinato ligands, have gained recognition as being one of the more versatile fluorophores due to their superior photophysical properties.[1,2] BODIPY derivatives are used as stable functional dyes in several fields such as light harvesters, laser dyes, fluorescent switches, and biomolecular labels.[3-6] They gained popularity as biological probes due to the easy modification of the ligand framework, extension of the chromophore, and substitution of the fluorine atoms.6 Figure 1 shows some commercially available BODIPY dyes used as biological probes.